Endocrine Abstracts

Insulin resistance has been suggested to have a pathogenic role in polycystic ovary syndrome (PCOS). The use of insulin sensitising drugs might therefore have a therapeutic role in its management.We studied 20 patients (mean age 32.6 years) with PCOS (diagnosed by the Rotterdam Consensus Workshop group criteria, 2003) before and after treatment with metformin (1.5–3 grams daily) for 6 to 12 months.Clinical features studied wer...

Hyperandrogenism of adrenal origin evidenced by elevated dehydroepiandrosterone sulphate (DHEAS) levels has been reported in 20% to 30% of patients with polycystic ovary syndrome.We studied 50 patients with PCOS (defined by the Rotterdam Consensus Workshop group criteria, 2003). Adrenal hyperandrogenaemia was defined as a DHEAS level> 10.5 micromoles/litre was found in 10 patients (20%). Clinical features studied were body mass index (BMI) and hirsut...